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Sixth, although some studies have begun to characterize the impact of smoking on gray matter in young adult/adolescent smokers [85, 86], the concurrent influence of marijuana [111] or alcohol use [112], and sex differences among smokers [17], as more studies accumulate regarding the influence of these and other important factors on gray matter alterations, it will become possible to better characterize the specificity of the meta-analytic effects identified herein

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