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Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies

Using the BioGRID database 26 as a reference, we find that interactions of 158 of these targets with human pathogenic viruses have been reported before, which represents a highly significant enrichment among reported interactions between enzymes and viruses (Fishers exact test p = 9.1 10 12 , odds ratio 1.93.4) and supports their central role in viral replication across diverse viruses

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The pre-dosed oral format removes the handling steps required by other presentations and simplifies study design wherever an oral route of exposure is preferred