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The inflammatory response in different areas was affected by the amount of copper accumulation [109]

To lower oxidative stress, glutathione maintains a balance between free radical generation and the bodys ability to combat them

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Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress (10)