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It has been suggested by some investigators to circumvent this problem by evaluating the response to an evoked painful visceral stimulus, such as bladder distension, either in normal volunteers, or in subjects with visceral pain

There is evidence that melatonin can be synthesized in other sites of the body (skin, gastrointestinal tract, retina, bone marrow, placenta and others) acting in an autocrine or paracrine manner (10)

Similar content being viewed by others Background Alzheimers disease (AD) is the most prevalent neurodegenerative disorder and is characterized by a progressive decline in learning and memory abilities