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Because the injection goes just under the skin, you may notice a bit of discomfort, but this is usually mild and goes away quickly

For instance, a study investigating the development of a stress cardiomyopathy mouse model found that daily administrations of ISO doses of 25 and 50 mg/kg for 14 consecutive days resulted in significant cardiac changes with minimal mortality 67

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When Higher Doses Are Sometimes Used Some people choose 600 mg to 1000 mg per day if they: have stubborn dark spots have hormonal pigmentation have heavy sun exposure want faster brightening have lifestyle stress Higher doses work best when the formulation is high quality and clean

The three standard injection sites are the abdomen (at least 2 inches from the navel), the front of the thigh (middle third), and the back of the upper arm