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How the Met allele affects BDNF secretion The Met allele disrupts the interaction between proBDNF and sortilin, a protein that directs BDNF into regulated secretory vesicles

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DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA