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Interstitial cystitis can also occur in domestic cats (Felis catus) and has been reported sporadically in other mammals, including cheetahs, dogs, llamas, and potbellied pigs.4,5 The central role of inflammation has been confirmed in the pathogenesis of interstitial cystitis, although the etiology of interstitial cystitis remains mostly unknown.6 Glycosaminoglycans make up a portion of the bladder mucosa

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This is based on studies involving TB-500 overexpression lentiviral vector in transfecting umbilical vein endothelial cells (HUVEC) and murine critical limb ischemia (CLI) models