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This interaction is crucial because it shields the peptide from rapid degradation and clearance by the kidneys
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The 4-hydroxyestrone pathway is additionally influenced by environmental toxins, so patients who have CYP1B1 SNPs are especially susceptible to estrogen-sensitive cancers
Cells were maintained as a single-cell culture (no colony formation) on COAT-1 pre-coated 6-well tissue culture plates in the Cellartis DEF-CS Culture System (Takara Bio, Inc.) at 37C in a humidified incubator supplied with 5% CO2