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Since decades ago, there have been reports showing arginine depletion by different forms of arginase-induced cell death in different kinds of cancer cells, but there were no arginase formulation developed for clinical use at that time [127, 128]

Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action

F., Grodzinsky, A

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