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Use of cannabidiol (CBD), an active ingredient in marijuana, in e-cigarettes among US middle and high school students is particularly concerning, with 21.3 percent reporting use in the previous month (205)

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Adverse reaction frequencies represent the proportion of subjects who experienced a treatmentemergent adverse reaction on at least one occasion in placebocontrolled trials for depression (n = 987) or smoking cessation (n = 1,013), or subjects who experienced an adverse reaction requiring discontinuation of treatment in an openlabel surveillance trial with bupropion sustainedrelease tablets (n = 3,100)

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