It is made from amino acids and plays a role in normal cellular function
Side effects are mainly seen with IV glutathione and include potential damage to kidneys, liver & thyroid
Over time, cells become less sensitive to this hormone and insulin resistance Leads to the potential development of Type 2 diabetes
Although siRNA studies show that GSTO1 is important for HCT116 cancer cell viability, knockdown of GSTO1 did not appear to affect C1-27 cytotoxicity, suggesting that other targets of C1-27 also may contribute to its cytotoxicity and have a compensatory effect (Supplementary Fig
However, confirming the up-regulated GST and GPx gene expression in pathogen-inoculated Tx7000 at 7 DPI, the functional assays provided evidence for enhanced GST-specific activity and GPx activity in both susceptible genotypes (Tx7000, BTx3042), leading to a net decline in GSH