found that dynamic data analysis significantly enhanced the evaluation of the therapeutic effects of drugs targeting tumor Gln metabolism (73, 74)
High glucose levels may switch microglia/macrophage polarization to a proinflammatory mode in microglia and NG2-glia coculture, significantly impairing NG2-glia differentiation and white matter repair
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
Yes, they are
On the other hand, designers usually negotiate with relevant stakeholders and play a role of coordinator, who strive to explore the regeneration potential of historic community and meet the needs and demands of multiple stakeholders
