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Approach to HCV Treatment in Persons with Substance Use HCV Treatment Eligibility The AASLD-IDSA HCV Guidance recommends treatment for all persons with chronic HCV, except those with a short life expectancy that HCV treatment cannot remediate, liver transplantation, or another directed therapy.[2,3] The general approach to considering initiation of HCV treatment for individuals with a prior history of substance use, including injection drug use, should be the same as in persons with no history of drug use