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First, a systematic search was conducted in PubMed, Web of Science, and Embase from inception to March 2026 using combinations of tinnitus AND (neurodegenerative diseases OR Alzheimer disease OR Parkinson disease) AND (treatment OR therapy OR intervention), supplemented with mechanism-specific terms paired with tinnitus (e.g., neuroinflammation, oxidative stress, BDNF, NMDA receptor, epigenetic)

Without a controlled study, it is impossible to isolate the effect

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Overall, peptide AOD 9604 greatly improves the results of dietary restrictions and exercise