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EXPERIMENTAL Animals The experiments were conducted using 60 male APPswe/PS1dE9/Blg (APP/PS1) mice with a mixed C57Bl6/Chg genetic background and 20 male C57Bl6/Chg (wild-type, WT) mice

Hypothelamic-Pituitary-Adrenal Axis Tumors of the cortisol-secreting cells of the adrenal cortex secrete excessive cortisol, resulting in excessive tissue protein degradation and muscle wasting Cushing's syndrome As a source of energy, amino acid carbon skeletons are directly oxidized, or, in the starved state, converted to glucose and ketone bodies, and then oxidized

Deficiency of lysosomal acid phosphatase

Some published research has explored a range of intake levels

Arrows indicate E2 complexes of PDH and OGDH containing lipoic acid (right)