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In other cell types such as spermatogonial cells, GSH depletion may induce autophagy 22

KIF5B-MET gene rearrangement with robust antitumor activity in response to crizotinib in lung adenocarcinoma

Additionally, a review in Neuroscience Letters discussed ALCAR's impact on cognitive performance and its neuroprotective properties (Hoffer et al., 2013)2

However, large randomized controlled trials, including the PANTHERIPF study, revealed limited clinical efficacy of NAC alone therapy in slowing disease progression or improving survival in unselected IPF cohort (138, 139, 150)

it was abandoned, almost certainly because no sponsor was willing to underwrite the next phase