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The seven most important carcinogens in tobacco smoke are shown in the table, along with DNA alterations they cause

Global adult tobacco survey (GATS)

Available at: (Accessed October 2023) Park, J.-A., Crotty Alexander, L.E

Heart disease is often correlated with chest pain, heart attack, heart failure, arrhythmias, or even death. Compounded by additional risk factors like bad cholesterol, high blood pressure, and overweight or obesity, a smokers risk of heart disease can escalate immensely

Specifically, nicotine and its primary metabolite cotinine are metabolized by the uridine 5-diphospho-glucuronosyltransferase (UGT) superfamily enzymes: specifically UGT2B10 for nicotine and cotinine, and UGT2B7, UGT2B15, and UGT2B17 are responsible for metabolizing androgens