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[Link] Lau, T, et al, Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. in Molecular Psychiatry , Volume 22, Issue 2 February 2017, pp 227 - 234

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Hence, the long-term therapeutic dose use and unnecessary overdose of APAP are of great concern as prolonged negligence may cost the nephrotoxicity that may lead to uremia and finally to kidney failure