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On the other hand, fructose, phosphoenolpyruvate, and glyceraldehyde-3-phosphate increase fosfomycin efficacy in Stenotrophomonas maltophilia strains that lack UhpT 89 , suggesting that membrane permeability can be modulated by a specific metabolite

The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

Acknowledgements This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A532B, 031A533A, 031A533B, 031A534A, 031A535A, 031A537A, 031A537B, 031A537C, 031A537D, 031A538A)

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