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Protection of the C-terminus is achieved via substitution of a glycine for the native proline at residue 171 (P171G) relative to mature (i.e., signal peptide removed) human FGF21, preventing degradation by FAP

Once this occurs, the hair loss becomes irreversible

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Society for Experimental Biology and Medicine (New York, N.Y.) vol

**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A