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As discussed in more detail in a white paper in preparation (24), it enters cell membranes as a lipophilic anion where it acts as a proton shunt (11), dissipating pH gradients across a range of host cellular-organelle membranes, including mitochondria, endosomes and lysosomes, and even the Golgi

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Each batch is produced in a U.S.-based facility and tested by third-party laboratories for purity and identity

As expected, in ligature induced experimental periodontitis, a considerable increase in vascular permeability in the gingival tissue was detected