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Zhao and colleagues developed an innovative two-stage nanoengineering strategy, using a gadoliniumeuropium metalorganic framework (GdEuMOF) loaded with tirapazamine (TPZ), designed to amplify TPZ activation through exacerbated hypoxia in breast tumors during microwave hyperthermia

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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

3a), which resemble earlier results from zebrafish 44,45