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Renal toxicity induced by adriamycin may arise from multi-organ damage primarily caused by the buildup of free radicals, which in turn induces membrane lipid peroxidation [55]

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Furthermore, we investigated the metabolic fate of U- 15 N glutamine in vivo by LCMS, which produces glutathione containing one 15 N atom via GSH de novo synthesis (Fig

More importantly, do other types of RCD have an effect on ferroptosis, and if so, is it synergistic or antagonistic