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Int J Mol Sci 25(5):2723 Zhao P et al (2024) Biopreparation of titanium dioxide nanoparticles mediated by Calendula officinalis flower extract for catalytic reduction of 4-nitrophenol and treatment of allergic conjunctivitis

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For example, by sponging the 3-UTR of GLS1 mRNA, miR-145 and miR-23a/b can decrease the expression of GLS1 ( via down-regulate GLS1 expression in dextran sulfate sodium (DSS)-induced colitis and house dust mite (HDM)/lipopolysaccharide (LPS)-induced asthma mouse models ( + T cells into Th17 cells by inhibiting GLS1-dependent glutaminolysis under Th17-polarizing condition, thus alleviating asthma in mouse model ( via binding to the hypoxia-responsive element (HRE) in the GLS1 gene ( + T cells from SLE patients, which is consistent with the results of GLS1 conditional knockout in the experimental autoimmune encephalomyelitis mouse model ( 4.2.2 Other enzymes Except for GLS1, GAC, GLUD1, GOT1, GOT2, GPT2 and IDH1 are other metabolic enzymes of glutaminolysis, implying that they are also potential regulatory targets

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Maintaining sufficient levels of glutathione and other antioxidants is essential for fortifying your immune system