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The isolated fraction induced delta-wave (slow-wave) sleep when injected into recipient animals giving the peptide its name and initiated one of the most distinctive research trajectories in neuropeptide biology: a compound with a clearly demonstrated biological name-property, an exceptionally wide pharmacological activity profile, and nearly five decades later a receptor that remains formally uncharacterised

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Vasireddi N, Vasireddi N, Shukla AJ, Nho SJ, Salata MJ, Voos JE, et al

The FDA recommends using a non-oral contraceptive method or adding a barrier method for 4 weeks after starting treatment and for 4 weeks after each dose increase

Statistical analysis The data are expressed as means SD