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SyN is commonly produced as a racemic (50:50) mixture of both the ( S )- and ( R )-enantiomers [14, 15] that then may be enriched to produce 99% ( S )-nicotine [15, 16]

Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence

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Even if nicotine is greatly reduced, a cigarette is still harmful