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The correct framing is that the design is explored to test whether multi pathway signalling produces measurable changes across a broader endpoint panel than single component designs

doi: 10.3390/ijms19030907 66 MoXShenXMoXYuFTanWDengZet al

J Genet Eng Biotechnol 20:29 Cui M, Cheng C, Zhang L (2022) High-throughput proteomics: a methodological mini-review

In vitro experiments were removed because they do not capture hostmicrobiotaliver interactions relevant to in vivo physiology (53 studies excluded)

It has a complex etiology and is linked to a variety of genetic and environmental risk factors, including smoking, light, and diet [19, 20]