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Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma

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These microclots prevent oxygen and vital nutrients from reaching the skeletal muscles and organs, contributing heavily to fatigue and tissue hypoxia