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It should be noted, however, that symptomatic vitamin E deficiency in healthy individuals who consume diets low in vitamin E has never been reported (58, 59)
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Its supplementation elevates NAD + , activating SIRT1 to regulate metabolism and suppress neuroinflammation ( 4.5 Limitations and future directions Limitations of the present study include incomplete recapitulation of human SAE heterogeneity by CLP and the lack of Nrf2 knockout/GSH inhibitor validation