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Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor - and interleukin-1-induced IKK/NF-B and JNK/AP-1 activation

The initiator of the pathophysiological process has not been elucidated yet, although acute gastrointestinal infections have been found to initiate the symptoms in a certain group of patients with IBS (post-infectious IBS) (81)

Additionally, hypoxia stimulates the expression of lipid transport proteins, such as CD36 and FABP3, facilitating the increased uptake of extracellular fatty acids which aids in tumor proliferation

Ni F, et al