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Nicotinamide nucleotide transhydrogenase NNT is an integral mitochondrial inner membrane protein in eukaryotes that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH utilizing the proton motive force generated by the electron transport chain (ETC)

They activate cyclic Adenosine Monophosphate (cAMP) by inhibiting mechanistic Target of Rapamycin Complex 1 (mTORC1), which is responsible for the additional decrease in IL-6 and TNF-alpha

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PMID: 21875351 (view on PubMed) Medical disclaimer This article is for general education and is not a substitute for personalized medical advice, diagnosis, or treatment