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Social deprivation was modelled using the Townsend score (area-level deprivation) and was derived from data on unemployment, car ownership, household overcrowding and owner occupation aggregated at postcode area (Townsend et al

These effects were mediated by the 5-HT4 receptor and associated with an increase in cAMP (cyclic adenosine monophosphate) content and the subsequent elevation of the phosphorylation state of Ca 2+ regulatory proteins [67]

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Replacing one source of nicotine with another can maintain dependence