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GHK-Cu is often used topically for direct skin benefits like collagen production

Important milestones in the GHK-Cu literature include the original 1973 identification of GHK as a plasma-derived cell proliferation factor, the recognition of the copper-binding role in the late 1970s, the wound healing and collagen research of the 1980s and 1990s, the establishment of GHK-Cu as a cosmetic ingredient in the 1990s and 2000s, and the transcriptomic expansion of the research literature in the 2000s and 2010s

Ingredient Compatibility Chart The limited compatibility of GHK-CU with common skincare actives is its main drawback compared to second-generation formulations

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