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It has been found that mitochondria isolated from the cortex and hippocampus of this RS mouse model produce significantly more ROS than those of WT mice [369]
L., Lin, M
New Engl J Med (2013) 368:157584
However, antioxidant supplements so far tested seem to offer little improvement over a well-balanced diet, possibly because of the choice of the substances tested or of an excessive dosage (Fair and Wynder, 1996
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