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Some studies showing the benefits of coffee enemas also included lifestyle changes (such as special diets and meditation), making it difficult to estimate the contribution of the enemas

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Life Sci 334:122210 Mohyeldin RH, Abdelnaser M, Sharata EE, Kotb ASM, Ali FF, Attya ME, Tawfik HM, Elrehany MA, Rofaeil RR (2025) Modulating platelet-activating factor by rupatadine attenuates gentamicin-induced nephrotoxicity in rats via NF-B/caspase-3 and Nrf2/HO-1 signaling cascades

Aktuelle Kardiologie 8 , 354361 (2019)

However, provided that treatment in the context of acute viral infections is short-termed and therefore fundamentally different from the long-term treatment in diabetes, phenformin could represent a viable treatment option