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Key points Blood pressure is determined by the interplay of genetic factors including rare variants with large effect sizes that cause monogenic hypertension syndromes and common variants with small effect sizes that contribute to polygenic cases of hypertension and non-genetic factors such as diet and the microbiome

Front Neurosci 9:431 Meunier S, Vernos I (2016) Acentrosomal microtubule assembly in mitosis: the where, when, and how

Gastrointestinal effects represent the primary concern

The most extensively documented mechanism involves upregulation of vascular endothelial growth factor, known as VEGF, and the broader angiogenic program