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In recent years, regular administration of probiotics, such as Bifidobacterium and Lactobacillus , has also been considered a potential method for preventing IBD (Manzoor et al., 2022), which further indicates the importance of the intestinal flora in IBD (Figure 2

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Choline is the major precursor of betaine, and it is used by the kidneys to maintain water balance and by the liver as a source of methyl-groups for methionine formation