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Transcriptomic analyses revealed the mechanisms of renal Fabry disease Gene expression profiles were obtained for GLA-mutant Fabry kidney organoids ( n = 3) and WT kidney organoids ( n = 2)
Animal studies also demonstrate its ability to reduce seizure threshold, alleviate depression-like behaviors, and modulate dopaminergic and serotonergic systemseven showing synergy with antidepressants and anxiolytics in preclinical models
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The effort needed to optimize these regimens can be experienced as aversive, promote frustration, and generate a desire to avoid such effort, aligning with a region of the brain called the anterior midcingulate cortex, as described by Lisa Feldman Barrett and colleagues
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