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N Engl J Med 365:173175 Bjrklund G, Saad K, Chirumbolo S, Kern JK, Geier DA, Geier MR, Urbina MA (2016) Immune dysfunction and neuroinflammation in autism spectrum disorder

However, susceptibility to proteolytic degradation and limited membrane permeability restrict their action to intracellular antioxidant pathways, thereby precluding the systemic immunomodulatory effects observed in other radioprotectants

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Thus, it is also possible that YfeA is not the direct 5OP sensor, but that another protein, upstream in the signaling cascade, binds 5OP