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These reports imply that abnormalities in thyroid function may be dispensable for the development of allergic rhinitis

10.1073/pnas.0705408104 16

Effective Skin Renewal: Gently exfoliates and renews the skin, revealing a smoother texture and leaving it vibrant and refreshed

(So it might be a good idea to combine arbutin with some direct tyrosinase inhibitors for more skin lightening effect.) All in all, arbutin is one of the better-known skin brightening agents, that's probably worth a try if pigmentation is an issue for you