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[2] Infection Fatality Rate (IFR) was calculated by Deaths / Cases and the rate was reported as 1.4%

Additionally, tobacco exposure downregulates p53, a critical tumor suppressor gene, facilitating genomic instability and malignant transformation [34]

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Our results indicate the relocation of bacteria from the mouth to the gut, particularly those of the Streptococcus genus, and the subsequent immune response in the gut, is the mechanism through which smoking helps protect against the disease