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doi: 10.1006/mgme.1999.2857 111 HanLMengLLiuJXieYKangRKlionskyDJet al

Others are steroids (like testosterone, estrogen, cortisol) or amines (like adrenaline or melatonin)

Moreover, the apoptotic machinery itself regulates mitochondrial clearance during terminal erythropoiesis, e.g., Nix protein mediates autophagy-dependent mitochondrial elimination in reticulocytes [116]

This highlights the need for further research into isoform-specific PI3K inhibitors to achieve better clinical outcomes with fewer off-target effects

And it does look like weve got some preliminary evidence showing either outcomes, meaning improvement in function in humans, or at very least the ability to increase certain compounds in the blood like growth hormone