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HHT, in conjunction with other chemotherapeutics, was dosed in pilot clinical trials at 3 mg/m 2 /day, which would result in an estimated ~1530 nM plasma concentration 75,76,77

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However, significant changes in pigmentation can take 3-6 months, depending on the type and severity of pigmentation you're treating

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doi: 10.3390/medicina61020254

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117 Uamek-Kozio M, Czuczwar SJ, Januszewski S, Pluta R (2020) Proteomic and genomic changes in tau protein, which are associated with Alzheimers disease after ischemia-reperfusion brain injury

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