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Addressing these limitations will be critical for translating mechanistic circadian insights into evidence-based clinical strategies

Homocysteine and cardiovascular disease Observational studies indicate that even moderately elevated blood concentrations of homocysteine raise the risk of cardiovascular disease (CVD), although randomized controlled trials of homocysteine-lowering therapy have generally not translated to reductions in adverse cardiovascular outcomes (26, 27)

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Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis

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