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Week three through four: If tolerating well, increase to every other day
In therapeutic settings, the effects of global GSH depletion or supplementation are likely to depend on disease context and cellular state
2.5.7 Keratinocyte proliferation inhibitors Psoriatic lesions are marked by keratinocyte hyperproliferation
Metabolic analysis Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured with a 24-well XF Extracellular Flux Analyzer (Agilent Technologies) and Seahorse Wave Controller Software (Agilent Technologies), according to the manufacturers instructions
( F ) Mean GSH/GSSG ratios in A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h
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