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10.1016/j.carbpol.2023.121633 114 Ghaz-JahanianM
The induction of protective cellular pathways, such as those involving vitagenes like sirtuins (a class of HDACs), has been proposed as a related neuroprotective strategy observed in other auditory pathologies like Menieres disease, which is characterized by tinnitus and considered a model of cochlear neurodegeneration (Scuto et al., 2020)
As depicted in Figure 4, unscavenged superoxide inactivates aconitase by displacing Fe +2 from the Fe-S cluster, which then promotes the formation of the damaging hydroxyl radical via reaction with H 2 O 2 and Fenton chemistry
Mitochondrion 13 , 246253 (2013)