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Notably, targeted inhibition of NRF2 with Brusatol counteracts this effect, effectively suppressing NRF2 activity and inducing apoptosis in breast cancer cells both in vitro and in vivo [170]

Plant Physiol 164:16361648 Noctor G, Mhamdi A, Chaouch S, Han Y, Neukermans J, Marquez- Garcia B, Queval G, Foyer CH (2012) Glutathione in plants: an integrated overview

all patients who met the eligibility criteria and provided consent were enrolled

At the completion of the trial period, body weight loss regardless of dose did not reach a plateau, suggesting more weight loss is possible with longer treatment duration

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