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Dihexa and its analogs bind with high affinity to HGF, induce Met phosphorylation in the presence of subthreshold levels of HGF, stimulate hippocampal spinogenesis and synaptogenesis equivalent with HGF [84], and promote neurogenesis and cerebroprotection (data in preparation for publication)

5.2.2.2 EGCG: established hepatotoxicity with regulatory response Emerging hepatotoxicity concerns have prompted regulatory action on epigallocatechin gallate (EGCG), particularly in concentrated supplement form