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Instead, the selected literature was analyzed and synthesized thematically, with studies grouped according to biological pathways (e.g., monoaminergic modulation, neurotrophic signaling, HPA-axis regulation, neuroinflammation, oxidative stress, and mitochondrial function) and level of evidence (preclinical versus clinical)
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188 HSP90 as a master regulator of oncogenic signaling networks HSP90 is frequently overexpressed in cancers such as cholangiocarcinoma, lung cancer, gastric cancer, breast cancer, and glioblastoma, and its elevated levels are often associated with poor prognosis
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