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The Lancet editorial notes Public Health England used the guesstimate despite it being based on the opinions of a small group of individuals with no prespecified expertise in tobacco control and an almost total absence of evidence

The active ingredient, triethylene glycol, functions as a glycolide that bonds with and neutralizes airborne organic compounds - including those produced by bacteria, which are the true biological source of most persistent and unpleasant car odors

cite web : CS1 maint: url-status (link) "Big Tobacco in the Big Apple: Billboards The Center for the Study of Tobacco and Society"

This is achieved with ozone generators and other specialized equipment, as described in the next section

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